ParkinsonCanadaV1, Main, Exploration, bibRecord, 002A20

The unilateral 6‐OHDA rat model of Parkinson's disease revisited: an electromyographic and behavioural analysis

Identifieur interne : 002A20 ( Main/Exploration ); précédent : 002A19; suivant : 002A21

The unilateral 6‐OHDA rat model of Parkinson's disease revisited: an electromyographic and behavioural analysis

Auteurs : Gerlinde A. Metz [Canada] ; Arthur Tse ; Mark Ballermann [Canada] ; Lori K. Smith [Canada] ; Karim Fouad [Canada]

Source :

European Journal of Neuroscience [ 0953-816X ] ; 2005-08.

RBID : ISTEX:5E8B9F886AFD20959EF0DE88F4249C82871EBFAB

English descriptors

KwdEn :
- Adrenergic Agents (toxicity), Animals, Apomorphine (pharmacology), Behavior, Animal (drug effects), Behavior, Animal (physiology), Disease Models, Animal, Dopamine Agonists (pharmacology), EMG, Electromyography (methods), Extremities (physiopathology), Female, Functional Laterality (drug effects), Functional Laterality (physiology), Locomotion (drug effects), Muscle, Skeletal (physiopathology), Oxidopamine (toxicity), Parkinson Disease (etiology), Parkinson Disease (physiopathology), Psychomotor Performance (drug effects), Psychomotor Performance (physiology), Rats, Rats, Inbred Lew, Stereotyped Behavior (drug effects), Substantia Nigra (drug effects), Substantia Nigra (pathology), Substantia Nigra (physiopathology), dopamine depletion, gait, locomotion, movement, walking.
MESH :
- chemical , pharmacology : Apomorphine, Dopamine Agonists.
- chemical , toxicity : Adrenergic Agents, Oxidopamine.
- drug effects : Behavior, Animal, Functional Laterality, Locomotion, Psychomotor Performance, Stereotyped Behavior, Substantia Nigra.
- etiology : Parkinson Disease.
- methods : Electromyography.
- pathology : Substantia Nigra.
- physiology : Behavior, Animal, Functional Laterality, Psychomotor Performance.
- physiopathology : Extremities, Muscle, Skeletal, Parkinson Disease, Substantia Nigra.
- Animals, Disease Models, Animal, Female, Rats, Rats, Inbred Lew.

Abstract

The characteristic locomotor disturbances of Parkinson's disease (PD) include shuffling gait, short steps and low walking velocity. In this study we investigated features of walking and turning in a rat model of PD caused by unilateral infusion of the neurotoxin 6‐hydroxydopamine (6‐OHDA). We assessed gait and electromyographic (EMG) patterns of the ankle flexor tibialis anterior and the knee extensor vastus lateralis of the hindlimb, and triceps brachii of the forelimb, during overgound locomotion, spontaneous rotation (turning) and apomorphine‐induced rotation. When compared with control rats, rats with unilateral dopamine depletion displayed a shuffling gait and short stride lengths. This locomotor pattern was accompanied by prolonged ankle flexor activity on the ipsilateral side, and prolonged activity of knee extensors on the contralateral side. The dopamine depletion also led to enhanced contraversive rotations after an apomorphine challenge. The EMG recordings during drug‐induced rotation suggested that hindlimb stepping was a reflective response to an active drive produced by forelimbs. The EMG recordings of the contralateral side during rotation were marked by reduced ankle flexor activity and increased knee extensor activity. Furthermore, EMG recordings indicated that dopamine‐agonists induce rotational bias by altering the coupling between ipsi‐ and contralateral hindlimbs, and between forelimbs. In straight walking, however, the gait of 6‐OHDA lesion animals reflected normal, coupled hindlimb stepping as controlled by spinal pattern generators. The data suggest that the unilateral rat model of PD resembles key features of human parkinsonian gait, and that asymmetric descending input may underlie the observed changes in gait patterns.

Url:

https://api-v5.istex.fr/document/5E8B9F886AFD20959EF0DE88F4249C82871EBFAB/fulltext/pdf

DOI: 10.1111/j.1460-9568.2005.04238.x

Affiliations:

Canada

Le document en format XML

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<front><div type="abstract" xml:lang="en">The characteristic locomotor disturbances of Parkinson's disease (PD) include shuffling gait, short steps and low walking velocity. In this study we investigated features of walking and turning in a rat model of PD caused by unilateral infusion of the neurotoxin 6‐hydroxydopamine (6‐OHDA). We assessed gait and electromyographic (EMG) patterns of the ankle flexor tibialis anterior and the knee extensor vastus lateralis of the hindlimb, and triceps brachii of the forelimb, during overgound locomotion, spontaneous rotation (turning) and apomorphine‐induced rotation. When compared with control rats, rats with unilateral dopamine depletion displayed a shuffling gait and short stride lengths. This locomotor pattern was accompanied by prolonged ankle flexor activity on the ipsilateral side, and prolonged activity of knee extensors on the contralateral side. The dopamine depletion also led to enhanced contraversive rotations after an apomorphine challenge. The EMG recordings during drug‐induced rotation suggested that hindlimb stepping was a reflective response to an active drive produced by forelimbs. The EMG recordings of the contralateral side during rotation were marked by reduced ankle flexor activity and increased knee extensor activity. Furthermore, EMG recordings indicated that dopamine‐agonists induce rotational bias by altering the coupling between ipsi‐ and contralateral hindlimbs, and between forelimbs. In straight walking, however, the gait of 6‐OHDA lesion animals reflected normal, coupled hindlimb stepping as controlled by spinal pattern generators. The data suggest that the unilateral rat model of PD resembles key features of human parkinsonian gait, and that asymmetric descending input may underlie the observed changes in gait patterns.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

The unilateral 6‐OHDA rat model of Parkinson's disease revisited: an electromyographic and behavioural analysis

The unilateral 6‐OHDA rat model of Parkinson's disease revisited: an electromyographic and behavioural analysis

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.